It's possible that the larger, Isuzu MTR chassis, heavily loaded, could deliver sub-10 mpg numbers. The smaller, gasoline NPR has a pretty thirsty GM V-8 and could also deliver sub-10's, heavily loaded. The NPR diesels are fuel efficient though (see below).
Most of the American gas and diesel medium-duty chassis trucks are likely to deliver sub-10 mpg numbers. The diesels tend to do better than gasoline drive trains for mileage.
Large diesel pickups can get into the mid-teens when loaded, high teens empty.
The most fuel efficient platforms are likely to be the import cab-over medium-duty chassis trucks. They have small-displacement turbo-diesels that deliver mid-to-high teens in the mpg department. These include the Isuzu NPR diesel, Mitsubishi-Fuso, Hino and Nissan UD medium-duty chassis trucks. The Fuso is available with 4wd.
Isuzu N-series:
http://www.isuzucv.com/nseries/index.html
Fuso Canter (Mitsubishi):
http://www.mitfuso.com/en-US/Models
Hino (Toyota):
http://www.hino.com/trucks/story_960...3f8946d53dd053
UD (Nissan):
http://www.udtrucksna.com/index.html
Another chassis that delivers good fuel economy is the Mercedes/Freightliner/Dodge Sprinter chassis. They also have small-displacement turbo-diesels and are available in chassis-cab configuration with dual rear wheels but are somewhat hard to find used.
Sprinter:
http://www.mbsprinterusa.com/sprinter/cab-chassis