Toyota recommends replacing the chain, guides and tensioner at approximately 80,000 mile intervals. Depending on how the truck has been driven and maintained, I've seen them go over 300,000 miles, and as little as 65,000.
If you're mechanically inclined, the parts / gaskets will cost ~$100-$150 and the job can be done in a few hours.
*edit to add: The later 22r/re engines (85-95) are different from the earlier models (early 85 and earlier 22R and 20R engines) in that they have a single row timing chain instead of the earlier two-row chain which was mostly indestructible. The single row chains ARE subject to wear at a higher rate compared to the two row chains which appears as stretching. This stretching causes the tensioner to lose its ability to take up slack which then causes the chain to slap against the exhaust side guide and in turn causes the guide to break. Once the guide breaks, it's only a matter of time before the chain slaps the timing cover and wears grooves through it, and into a coolant passage. Guess what happens next? You have coolant in your crankcase and in won't be long until you either overheat due to no coolant flow and destroy your engine's bearings due to coolant in the oil,
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